Genetic Diversity of Blastocystis in Livestock and Zoo Animals.


Alfellani, MA; Taner-Mulla, D; Jacob, AS; Imeede, CA; Yoshikawa, H; Stensvold, CR; Clark, CG; (2013) Genetic Diversity of Blastocystis in Livestock and Zoo Animals. Protist, 164 (4). pp. 497-509. ISSN 1434-4610 DOI: https://doi.org/10.1016/j.protis.2013.05.003

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Abstract

: Blastocystis is a common unicellular anaerobic eukaryote that inhabits the large intestine of many animals worldwide, including humans. The finding of Blastocystis in faeces in mammals and birds has led to proposals of zoonotic potential and that these hosts may be the source of many human infections. Blastocystis is, however, a genetically diverse complex of many distinct organisms (termed subtypes; STs), and sampling to date has been limited, both geographically and in the range of hosts studied. In order to expand our understanding of host specificity of Blastocystis STs, 557 samples were examined from various non-primate animal hosts and from a variety of different countries in Africa, Asia and Europe. STs were identified using 'barcoding' of the small subunit rRNA gene using DNA extracted either from culture or directly from faeces. The host and geographic range of several STs has thereby been greatly expanded and the evidence suggests that livestock is not a major contributor to human infection. Two new STs were detected among the barcode sequences obtained; for these, and for three others where the data were incomplete, the corresponding genes were fully sequenced and phylogenetic analysis was undertaken.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases
Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 23770574
Web of Science ID: 322929200004
URI: http://researchonline.lshtm.ac.uk/id/eprint/989894

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