A new approach to the definition of seroconversion following vaccination in a population with high background antibody concentrations.


Chandramohan, D; Coleman, P; Nelson, C; Greenwood, B; (2007) A new approach to the definition of seroconversion following vaccination in a population with high background antibody concentrations. Vaccine, 25S1. A58-A62. ISSN 0264-410X DOI: 10.1016/j.vaccine.2007.04.042

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Abstract

Licensure of meningitis vaccines is increasingly being made on the basis of safety and immunogenicity. For meningococcal vaccines, a measure of immunogenicity is seroconversion, usually defined as a four-fold increase in rSBA titre. However, this definition is likely to underestimate seroconversion in settings with high background immunity. Using data from a study of the immunogenicity of meningococcal polysaccharide vaccines undertaken in Ghana, a logistic regression model to estimate the probability of seroconversion as a function of pre-vaccination titre has been developed. The seroconversion rate (91%) based on a variable-fold increase in rSBA titre derived from the model was a more plausible estimate of immunogenicity than the seroconversion rate (32%) based on the fixed four-fold increase in rSBA.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Vaccine Centre
PubMed ID: 17524529
Web of Science ID: 249521900012
URI: http://researchonline.lshtm.ac.uk/id/eprint/9880

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