Migration through host cells activates Plasmodium sporozoites for infection


Mota, MM; Hafalla, JCR; Rodriguez, A; (2002) Migration through host cells activates Plasmodium sporozoites for infection. Nature medicine, 8 (11). pp. 1318-1322. ISSN 1078-8956 DOI: https://doi.org/10.1038/nm785

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Abstract

Plasmodium sporozoites, the infective stage of the malaria parasite transmitted by mosquitoes, migrate through several hepatocytes before infecting a final one. Migration through hepatocytes occurs by breaching their plasma membranes, and final infection takes place with the formation of a vacuole around the sporozoite. Once in the liver, sporozoites have already reached their target cells, making migration through hepatocytes prior to infection seem unnecessary. Here we show that this migration is required for infection of hepatocytes. Migration through host cells, but not passive contact with hepatocytes, induces the exocytosis of sporozoite apical organelles, a prerequisite for infection with formation of a vacuole. Sporozoite activation induced by migration through host cells is an essential step of Plasmodium life cycle.

Item Type: Article
Keywords: Animals, Cell Line, Exocytosis, Hepatocytes, Mice, Mice, Inbred BALB C, Plasmodium, Animals, Cell Line, Exocytosis, Hepatocytes, parasitology, Mice, Mice, Inbred BALB C, Plasmodium, physiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 12379848
Web of Science ID: 179221200040
URI: http://researchonline.lshtm.ac.uk/id/eprint/9826

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