Incorporating Household Structure into a Discrete-Event Simulation Model of Tuberculosis and HIV

Mellor, GR; Currie, CSM; Corbett, EL; (2011) Incorporating Household Structure into a Discrete-Event Simulation Model of Tuberculosis and HIV. ACM transactions on modeling and computer simulation, 21 (4). ISSN 1049-3301 DOI:

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Human immunodeficiency virus (HIV) increases the risks of developing tuberculosis (TB) disease following infection, and speeds up disease progression. This has had a devastating effect on TB epidemics in sub-Saharan Africa, where incidence rates have more than trebled in the past twenty years. Current control methods for TB disease have failed to keep pace with this growth, and there is an urgent need to find TB control strategies that are effective in high-HIV prevalent settings. This article describes a discrete-event simulation model of endemic TB that includes the effects of HIV and of household structure on the transmission dynamics of TB. Incorporating a social structure allows us to compare the effectiveness of contact-tracing interventions with case-finding targeted at high risk groups. We describe the modeling of the household structure in some detail, as this has applications to the modeling of other infectious diseases.

Item Type: Article
Keywords: Disease modeling, simulation, health, tuberculosis, HIV, developing, countries, resistant mycobacterium-tuberculosis, dynamics, epidemics, infection, disease, transmission, reinfection, progression, population, countries, g a, 2001
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
Web of Science ID: 294423300005


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