The risk of sequelae due to pneumococcal meningitis in high-income countries: a systematic review and meta-analysis.


Jit, M; (2010) The risk of sequelae due to pneumococcal meningitis in high-income countries: a systematic review and meta-analysis. The Journal of infection, 61 (2). pp. 114-24. ISSN 0163-4453 DOI: https://doi.org/10.1016/j.jinf.2010.04.008

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Abstract

OBJECTIVES: To determine the risk of various kinds of sequelae in survivors of meningitis due to Streptococcus pneumoniae, as well as the influence of co-factors such as study design, study population and treatment on this risk. METHODS: MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1 September 1991 to 18 June 2009 for original articles on pneumococcal meningitis sequelae. Prevalence of sequelae was pooled using random effects meta-analysis. Studies were appraised for the influence of referral bias, external validity of study populations, testing procedure and publication bias. RESULTS: Data were extracted from 63 studies involving 3408 pneumococcal meningitis survivors. The pooled prevalence of any reported sequelae from 48 studies was 31.7% (95% confidence interval 27.2-36.3%) using a random effects model (Cochran-Q = 277, p < 0.01). Differences in studies due to design, study population and treatment were not significant. The pooled prevalence of hearing loss, seizures, hydrocephalus, spasticity/paresis, cranial nerve palsies and visual impairment was 20.9% (17.1-24.7%), 6.5% (3.3-9.7%), 6.8% (3.3-10.2%), 8.7% (6.4-11.0%), 12.2% (5.3-19.1%) and 2.4% (0-5.7%) respectively. CONCLUSIONS: The burden of sequelae due to pneumococcal meningitis remains high in the reviewed studies.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 20433866
Web of Science ID: 280194500002
URI: http://researchonline.lshtm.ac.uk/id/eprint/97665

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