Case management of malaria in pregnancy


Nosten, F; McGready, R; Mutabingwa, T; (2007) Case management of malaria in pregnancy. The Lancet infectious diseases, 7 (2). pp. 118-125. ISSN 1473-3099 DOI: https://doi.org/10.1016/S1473-3099(07)70023-3

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Abstract

In all malarious areas, infection by any of the main human plasmodial species during pregnancy is detrimental to the mother and the fetus. These potentially fatal infections must be prevented, but when they develop they require prompt diagnosis and treatment. Current tools to detect malaria parasites in pregnant women are often not used and remain too insensitive to detect a low parasitaemia. The kinetics, safety and efficacy of available antimalarial drugs are poorly documented because pregnant women are systematically excluded from clinical trials. A considerable effort, involving clinical trials, is urgently required to improve the diagnosis and case management of malaria during pregnancy if the morbidity and mortality of maternal malaria is to be reduced.

Item Type: Article
Keywords: UNCOMPLICATED FALCIPARUM-MALARIA, PLUS SULFADOXINE-PYRIMETHAMINE, PLASMODIUM-VIVAX MALARIA, ANTIMALARIAL-DRUG, IRON SUPPLEMENTATION, ATOVAQUONE-PROGUANIL, RANDOMIZED-TRIAL, EASTERN SUDAN, SEVERE ANEMIA, DOUBLE-BLIND, Adult, Animals, Antimalarials, administration & dosage, adverse effects, therapeutic use, Female, Humans, Malaria, diagnosis, drug therapy, parasitology, Malaria, Falciparum, diagnosis, drug therapy, parasitology, Pregnancy, Pregnancy Complications, Parasitic, diagnosis, drug therapy, parasitology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Malaria Centre
PubMed ID: 17251082
Web of Science ID: 243748900024
URI: http://researchonline.lshtm.ac.uk/id/eprint/9639

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