Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort

Archer, HA; MacFarlane, F; Price, S; Moore, EK; Pepple, T; Cutler, D; Frost, C; Fox, NC; Rossor, MN; (2006) Do symptoms of memory impairment correspond to cognitive impairment: a cross sectional study of a clinical cohort. International journal of geriatric psychiatry, 21 (12). pp. 1206-1212. ISSN 0885-6230 DOI:

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Background Symptoms of memory loss are a common complaint within the general population and a frequent reason for seeking medical advice. However, the clinical relevance of these symptoms to future development of neurodegenerative disease is uncertain. The aim of this study is to characterise a cohort of individuals with symptoms of memory loss and varying memory impairment, who will be followed longitudinally with serial neuropsychology and neuroimaging to evaluate the clinical relevance of symptoms of memory loss. Method Fifty-eight subjects with symptoms of memory loss were recruited from the National Hospital for Neurology and Neurosurgery. All subjects underwent clinical assessment, APOE4 genotyping, neuroimaging and neuropsychological tests. Results Those with mild cognitive impairment (MCI) had an increased prevalence of the APOE4 allele, impaired performance on tests of memory, measures of IQ and naming compared to controls. Baseline brain volumes were decreased and ventricular size increased. Those with symptoms of memory loss but no cognitive impairment (SNCI) performed significantly worse on tests of memory than the control group. Conclusions The MCI represent a group with multiple risk factors for progression to AD. The SNCI group may represent a heterogeneous group with some individuals in the early stages of AD whilst others' memory complaints are more likely linked to anxiety or personality traits. Copyright (c) 2006 John Wiley & Sons, Ltd.

Item Type: Article
Keywords: Alzheimer's disease, symptoms, memory loss, clinical, mild cognitive, impairment, HIPPOCAMPAL ATROPHY, ALZHEIMERS-DISEASE, COMPLAINTS, DEMENTIA, MRI, DECLINE, VOLUME, CORRELATE, GENOTYPE, RATES
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16977678
Web of Science ID: 243086300014


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