Association between haemoglobin variants S and C and Mycobacterium ulcerans disease (Buruli ulcer): a case-control study in Benin

Nackers, F; Tonglet, R; Slachmuylder, V; Johnson, RC; Robert, A; Zinsou, C; Glynn, JR; Portaels, F; Gala, JL; (2007) Association between haemoglobin variants S and C and Mycobacterium ulcerans disease (Buruli ulcer): a case-control study in Benin. Tropical medicine & international health, 12 (4). pp. 511-518. ISSN 1360-2276 DOI:

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Risk factors for Buruli ulcer (BU) are poorly understood. We conducted a case-control study in southern Benin to investigate the association between haemoglobin variants S or C and BU, and particularly the association between haernoglobinopathies HbSS/SC and BU osteomyelitis. We compared the haemoglobin genotype of 179 patients with BU and 44 with BU osteomyelitis to that of 242 community controls. We found no evidence of an increased risk of BU according to the presence of haemoglobin variants S and/or C [odds ratio adjusted for sex, age, region of residence and ethnicity: 1.24 (95%CI: 0.80-1.93), P = 0.34]. Haemoglobin variants S and C are unlikely to play a role in the BU burden. However, haemoglobinopathies HbSS/SC were more frequent among BU osteomyelitis patients than among controls (6.8% vs. 1.0%, Fisher's exact P-value = 0.045), which may suggest that those disorders facilitate growth of Mycobacterium ulcerans in the bone matrix.

Item Type: Article
Keywords: case-control studies, Mycobacterium ulcerans, Benin, haemoglobin S, haemoglobin C, osteomyelitis, HIV-POSITIVE PATIENT, AQUATIC INSECTS, INFECTION, Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Anemia, Sickle Cell, complications, epidemiology, genetics, Benin, epidemiology, Case-Control Studies, Child, Child, Preschool, Female, Gene Frequency, Genotype, Hemoglobin C, genetics, Hemoglobin C Disease, complications, epidemiology, genetics, Hemoglobin, Sickle, genetics, Hemoglobins, genetics, Humans, Infant, Male, Middle Aged, Mycobacterium Infections, Atypical, complications, epidemiology, genetics, Mycobacterium ulcerans, genetics, Osteomyelitis, complications, epidemiology, genetics, Risk Factors, Sex Distribution
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 17445142
Web of Science ID: 246065600006


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