Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy


Checkley, AM; Pepin, J; Gibson, WC; Taylor, MN; Jager, HR; Mabey, DC; (2007) Human African trypanosomiasis: diagnosis, relapse and survival after severe melarsoprol-induced encephalopathy. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101 (5). pp. 523-526. ISSN 0035-9203 DOI: https://doi.org/10.1016/j.trstmh.2006.12.001

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Abstract

We describe a case of human African trypanosomiasis with a number of unusual features. The clinical presentation was subacute, but the infection was shown to be due to Trypanosoma brucei rhodesiense. The infection relapsed twice following treatment and the patient developed a melarsoprol-associated encephatopathy. Magnetic resonance imaging (MRI) findings were suggestive of microhaemorrhages, well described in autopsy studies of encephalopathy but never before shown on MRI. The patient survived severe encephalopathy with a locked-in syndrome. Our decision to provide ongoing life support may be useful to physicians treating similar cases in a setting where intensive care facilities are available. (c) 2007 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: trypanosomiasis, Trypanosoma brucei rhodesiense, melarsoprol, encephalopathy, magnetic resonance imaging, RISK-FACTORS, GAMBIENSE, MRI
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Neglected Tropical Diseases Network
PubMed ID: 17270227
Web of Science ID: 245785200017
URI: http://researchonline.lshtm.ac.uk/id/eprint/9522

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