Screening for tuberculosis among 2381 household contacts of sputum-smear-positive cases in The Gambia


Jackson-Sillah, D; Hill, PC; Fox, A; Brookes, RH; Donkor, SA; Lugos, MD; Howie, SRC; Fielding, KR; Jallow, A; Lienhardt, C; Corrah, T; Adegbola, RA; McAdam, KP; (2007) Screening for tuberculosis among 2381 household contacts of sputum-smear-positive cases in The Gambia. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101 (6). pp. 594-601. ISSN 0035-9203 DOI: 10.1016/j.trstmh.2007.02.001

Full text not available from this repository.

Abstract

Contact investigation is a key component of tuberculosis (TB) control in developed, but not developing, countries. We aimed to measure the prevalence of TB among household contacts of sputum-smear-positive TB cases in The Gambia and to assess the sensitivity of an enzyme-linked immunospot (ELISPOT) assay in this regard. Household contacts of adult smear-positive TB patients were assessed by questionnaire, purified protein derivative (PPD) skin test, ELISPOT assay, physical examination, chest X-ray and sputum/gastric aspirate. Thirty-three TB cases were identified from 2174 of 2381 contacts of 317 adult smear-positive pulmonary TB patients, giving a prevalence of 1518/100000. The cases identified tended to have milder disease than those passively detected. The sensitivity of ESAT-6/CFP-10 ELISPOT test as a screening test for TB disease was estimated as 71%. Fifty-six per cent of contacts with a PPD skin test result >= 10 mm induration had detectable responses to ESAT-6/CFP-10 by ELISPOT, 11% with a negative PPD skin test (<10 mm) had a positive ESAT-6/CFP-10 response. Active screening for TB among contacts of TB patients may have a role in TB control in The Gambia. These individuals are a high-risk group, and the disease identified is less advanced than that found through passive case detection. An ELISPOT assay was relatively insensitive as a screening test for TB. (C) 2007 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: tuberculosis, Mycobacterium tuberculosis, screening, tuberculin skin, test, ELISPOT, The Gambia, SECRETED ANTIGENIC TARGET, T-CELL RESPONSES, MYCOBACTERIUM-TUBERCULOSIS, PULMONARY TUBERCULOSIS, RISK-FACTORS, SKIN-TEST, INFECTION, DIAGNOSIS, DISEASE, ASSAY
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 17368495
Web of Science ID: 246834400012
URI: http://researchonline.lshtm.ac.uk/id/eprint/9507

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
311Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item