Core outcome domains for controlled trials and clinical recordkeeping in eczema: international multiperspective delphi consensus process.


Schmitt, J; Langan, S; Stamm, T; Williams, HC; Harmonizing Outcome Measurements in Eczema (HOME) Delphi panel, ; (2011) Core outcome domains for controlled trials and clinical recordkeeping in eczema: international multiperspective delphi consensus process. The Journal of investigative dermatology, 131 (3). pp. 623-30. ISSN 0022-202X DOI: https://doi.org/10.1038/jid.2010.303

Full text not available from this repository.

Abstract

There is wide variation in the use of outcome measures for eczema. We performed a three-stage web-based international Delphi exercise to develop consensus-based sets of core outcome domains for eczema for "controlled trials" and "clinical recordkeeping". A total of 57 individuals from four stakeholder groups (consumers, clinical experts, regulatory agency representatives, and journal editors) representing 13 countries were asked to rate the importance of 19 outcome domains for eczema and to choose which domains should be included in two core sets of outcomes. Forty-six individuals (81%) participated. Participants received standardized feedback, including the group median, interquartile range, and previous responses, and the assessment was repeated in two subsequent rounds. We defined consensus a priori if at least 60% of the members of at least three stakeholder groups, including consumers, recommended domain inclusion in the core set. Consensus was achieved for inclusion of symptoms, physician-assessed clinical signs, and a measurement for long-term control of flares in the core set of outcome domains for eczema trials. We recommend including these three core outcomes in future eczema trials in order to enhance clinical interpretability and to enable meta-analyses across different studies. For recordkeeping, consensus was reached to regularly monitor eczema symptoms in clinical practice. Future work is needed to select which existing or new scales should be used to measure the domains identified as relevant for the core set.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
PubMed ID: 20944653
Web of Science ID: 287229700014
URI: http://researchonline.lshtm.ac.uk/id/eprint/935

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
263Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item