The second century of Campylobacter research: recent advances, new opportunities and old problems.


Dorrell, N; Wren, BW; (2007) The second century of Campylobacter research: recent advances, new opportunities and old problems. Current opinion in infectious diseases, 20 (5). pp. 514-8. ISSN 0951-7375 DOI: https://doi.org/10.1097/QCO.0b013e3282a56b15

Full text not available from this repository. (Request a copy)

Abstract

PURPOSE OF REVIEW: Despite the prevalence of Campylobacter jejuni and the importance of the disease, investigations into pathogenesis have been restricted because of the absence of a convenient animal model of disease. In particular it is still unclear how C. jejuni infection causes diarrhoea. RECENT FINDINGS: Recent developments in improved models of infection and studies on the innate immune responses have provided a deeper understanding of host-pathogen interactions. From the organism's perspective, further genomics-based information including two new genome sequences has provided much basic information, particularly relating to cell surface glycostructures. SUMMARY: Research over the last few years is starting to address the gaps in our knowledge of how this important human pathogen interacts with host cells and causes diarrhoeal disease. Further research is required for a detailed understanding of these interactions and also to develop intervention strategies to reduce the burden of C. jejuni-associated disease.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 17762786
Web of Science ID: 249966600011
URI: http://researchonline.lshtm.ac.uk/id/eprint/9236

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
289Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item