Pertussis vaccine effectiveness in reducing clinical disease, transmissibility and proportion of cases with a positive culture after household exposure in Brazil


Baptista, PN; Magalhaes, V; Rodrigues, LC; Rocha, MW; Pimentel, AM; (2006) Pertussis vaccine effectiveness in reducing clinical disease, transmissibility and proportion of cases with a positive culture after household exposure in Brazil. The Pediatric infectious disease journal, 25 (9). pp. 844-6. ISSN 0891-3668 DOI: 10.1097/01.inf.0000232642.25495.95

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Abstract

In household outbreaks of pertussis, children <5 years of age who received at least 3 doses of vaccine had 12% less clinical disease; vaccinated cases were 63% less culture-confirmed and transmitted infection to 62% fewer contacts. Three doses of pertussis vaccine are likely to decrease circulation of Bordetella pertussis by reducing the proportion of bacteriologically positive cases and transmissibility.

Item Type: Article
Keywords: Adolescent, Adult, Child, Child, Preschool, Disease Transmission, Horizontal/*prevention & control, Family Characteristics, Female, Humans, Infant, Infant, Newborn, Male, Pertussis Vaccine/*therapeutic use, Whooping Cough/*prevention & control/transmission, Adolescent, Adult, Child, Child, Preschool, Disease Transmission, Horizontal, prevention & control, Family Characteristics, Female, Humans, Infant, Infant, Newborn, Male, Pertussis Vaccine, therapeutic use, Whooping Cough, prevention & control, transmission
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Vaccine Centre
PubMed ID: 16940847
Web of Science ID: 240262200018
URI: http://researchonline.lshtm.ac.uk/id/eprint/9188

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