[Antibiotic-resistance in Italy: activity of the first year of the surveillance project AR-ISS]


Boccia, D; D'Ancona, F; Salmaso, S; Monaco, M; Del Grosso, M; D'Ambrosio, F; Giannitelli, S; Lana, S; Fokas, S; Pantosti, A; Gruppo AR-ISS, ; (2005) [Antibiotic-resistance in Italy: activity of the first year of the surveillance project AR-ISS]. Annali di igiene, 17 (2). pp. 95-110. ISSN 1120-9135

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Abstract

: The antibiotic resistance surveillance project AR-ISS, started in 2001, is based on a network of 62 sentinel microbiological laboratories throughout the country. The laboratories collect and transmit data to the Istituto Superiore di Sanità on the antibiotic susceptibility of bloodstream isolates of 7 species: Staphylococcus aureus, Streptococcus pneumoniae, Enterococcus faecalis/faecium, Klebsiella pneumoniae/oxytoca ed Escherichia coli. They also send selected bacterial strains for further characterization. Results of the first year of surveillance are presented and are compared with data from the previous study EARSS-Italia and from other European countries. Oxacillin resistance in S. aureus appears to be stable, however, it remains one of the highest in Europe (41,5%). No strain with intermediate susceptibility or resistance to vancomycin has been isolated. In S. pneumoniae, the level of penicillin resistance is moderate (10,8%), but macrolide resistance has increased greatly (37,6% versus 28,6% of the previous study), following a tendency common to several European countries. Unexpectedly, vancomycin resistance in E. faecium was found to be 18%, the highest in Europe. Presumptive ESBL production in Gram-negative organisms can be estimated at 20% in Klebsiella and 1% in E. coli. Ampicillin and ciprofloxacin resistance in E. coli (respectively 50% and 18%) are among the highest in Europe. In conclusion, the rate of antibiotic resistance in the species studied is worrisome and requires continuing monitoring. Although some activities of AR-ISS need improvements, the surveillance has the potentiality to produce relevant and representative data about antibiotic resistance in Italy that can be used for comparison at the European level.<br/>

Item Type: Article
Keywords: Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/*pharmacology, Bacteremia/drug therapy/epidemiology/*microbiology, Child, Child, Preschool, *Drug Resistance, Bacterial, Enterococcus faecalis/drug effects, Escherichia coli/drug effects, Female, Health Surveys, Humans, Infant, Italy/epidemiology, Klebsiella oxytoca/drug effects, Klebsiella pneumoniae/drug effects, Male, Microbial Sensitivity Tests/standards/*statistics & numerical data, Middle Aged, Quality Assurance, Health Care, *Sentinel Surveillance, Serotyping, Staphylococcus aureus/drug effects, Streptococcus pneumoniae/drug effects, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, pharmacology, Bacteremia, drug therapy, epidemiology, microbiology, Child, Child, Preschool, Drug Resistance, Bacterial, Enterococcus faecalis, drug effects, Escherichia coli, drug effects, Female, Health Surveys, Humans, Infant, Italy, epidemiology, Klebsiella oxytoca, drug effects, Klebsiella pneumoniae, drug effects, Male, Microbial Sensitivity Tests, standards, statistics & numerical data, Middle Aged, Quality Assurance, Health Care, Sentinel Surveillance, Serotyping, Staphylococcus aureus, drug effects, Streptococcus pneumoniae, drug effects
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 16676730
URI: http://researchonline.lshtm.ac.uk/id/eprint/9096

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