[Antibiotic microbial resistance surveillance in invasive infections caused by Streptococcus pneumoniae and Staphylococcus aureus: the EARSS (European Antimicrobial Resistance Surveillance System) project in Italy (April 1999-April 2000)]


Moro, ML; Pantosti, A; Boccia, D; (2002) [Antibiotic microbial resistance surveillance in invasive infections caused by Streptococcus pneumoniae and Staphylococcus aureus: the EARSS (European Antimicrobial Resistance Surveillance System) project in Italy (April 1999-April 2000)]. Annali di igiene, 14 (5). pp. 361-71. ISSN 1120-9135

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Abstract

This paper presents the results of an Italian multicentric study conducted in the period April 1999-April 2000 in 64 clinical microbiology laboratories, aimed at collecting antimicrobial resistance data using a standard European protocol (EARSS Project, European Antimicrobial Surveillance System). A total of 1701 strains of Staphylococcus aureus were isolated from blood and 367 strains of Streptococcus pneumoniae were isolated from blood (72.7%) or from CSF (27.3%). Methicillin resistance in S. aureus was found to be 42.1%; it was significantly higher in adults (RR = 6.6, CI 95% 2.5-17.0), in hospitals of Centre and North of Italy (respectively RR = 1.45, CI 95% 1.1-2.0; RR = 1.6, CI 95% 1.1-2.2), and in intensive care and surgery units (respectively RR = 1.8, IC 95% 1.6-2.0 and RR = 1.7, CI 95% 1.4-1.9). Penicillin resistance in S. pneumoniae was found to be 12.1%; it was higher in South Italy (RR = 3.5, CI 95% 1.9-6.6, in meningitis compared to sepsis (RR = 2.5, CI 95% 1.4-2.5) and in intensive care units compared to other departments (RR = 2.2, CI 95% 1.0-4.8). The level of erythromycin resistance in S. pneumoniae was of 28.2%, reaching 56.4% in penicillin resistant strains. These results suggest that a continued surveillance and effective control measures are required.

Item Type: Article
Keywords: Adolescent, Adult, Age Factors, Aged, Anti-Bacterial Agents/pharmacology, Blood/microbiology, Cerebrospinal Fluid/microbiology, Child, Child, Preschool, *Drug Resistance, Bacterial, Erythromycin/pharmacology, Female, Humans, Infant, Infant, Newborn, Male, Methicillin Resistance, Microbial Sensitivity Tests, Middle Aged, Penicillin Resistance, Pneumococcal Infections/*drug therapy, Staphylococcal Infections/*drug therapy, Staphylococcus aureus/*drug effects/isolation & purification, Streptococcus pneumoniae/*drug effects/isolation & purification, Adolescent, Adult, Age Factors, Aged, Anti-Bacterial Agents, pharmacology, Blood, microbiology, Cerebrospinal Fluid, microbiology, Child, Child, Preschool, Drug Resistance, Bacterial, Erythromycin, pharmacology, Female, Humans, Infant, Infant, Newborn, Male, Methicillin Resistance, Microbial Sensitivity Tests, Middle Aged, Penicillin Resistance, Pneumococcal Infections, drug therapy, Staphylococcal Infections, drug therapy, Staphylococcus aureus, drug effects, isolation & purification, Streptococcus pneumoniae, drug effects, isolation & purification
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 12508445
URI: http://researchonline.lshtm.ac.uk/id/eprint/9086

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