Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial.
Semba, RD;
Kumwenda, J;
Zijlstra, E;
Ricks, MO;
van Lettow, M;
Whalen, C;
Clark, TD;
Jorgensen, L;
Kohler, J;
Kumwenda, N;
+2 more...Taha, TE;
Harries, AD;
(2007)
Micronutrient supplements and mortality of HIV-infected adults with pulmonary TB: a controlled clinical trial.
The international journal of tuberculosis and lung disease, 11 (8).
pp. 854-859.
ISSN 1027-3719
https://researchonline.lshtm.ac.uk/id/eprint/8961
Permanent Identifier
Use this permanent URL when citing or linking to this resource.
https://researchonline.lshtm.ac.uk/id/eprint/8961
Abstract
SETTING: Zomba and Blantyre, Malawi, Africa. OBJECTIVES: To determine whether daily micronutrient supplementation reduces the mortality of human immunodeficiency virus (HIV) infected adults with pulmonary tuberculosis (TB). DESIGN: A randomised, controlled clinical trial of micronutrient supplementation for HIV-positive and HIV-negative adults with pulmonary TB. Participants were enrolled at the commencement of chemotherapy for sputum smear-positive pulmonary TB and followed up for 24 months. RESULTS: A total of 829 HIV-positive and 573 HIV-negative adults were enrolled. During follow-up, 328 HIV-positive and 17 HIV-negative participants died. The proportion of HIV-positive participants who died in the micronutrient and placebo groups was 38.7% and 40.4%, respectively (P = 0.49). Micronutrient supplementation did not reduce mortality (hazard ratio [HR] 0.93, 95%CI 0.75-1.15) among HIV-positive adults. CONCLUSIONS: Micronutrient supplementation at the doses used in this study does not reduce mortality in HIV-positive adults with pulmonary TB in Malawi.
