Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents.


Everett, DB; Weiss, HA; Changalucha, J; Anemona, A; Chirwa, T; Ross, DA; Watson-Jones, D; Parry, JV; Hayes, R; Mabey, DC; (2007) Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents. Tropical medicine & international health, 12 (11). pp. 1323-6. ISSN 1360-2276 DOI: https://doi.org/10.1111/j.1365-3156.2007.01933.x

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Abstract

OBJECTIVE: To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania. METHODS: A cross-sectional survey of 7333 Tanzanian adolescents and young adults was carried out. Sera testing positive by the Murex assay were further evaluated using a battery of other EIA which detect either antibody to HIV-1 or p24 antigen, and by PCR using pol primers. RESULTS: Of the 674 sera testing positive by the Murex assay, only 53 (7.9%) were confirmed. The specificity of the Murex assay was 91.5%. CONCLUSIONS: Serological tests for HIV may perform differently in different populations. New diagnostic tests should not be introduced into populations in which they have not been evaluated.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 17949396
Web of Science ID: 251716900008
URI: http://researchonline.lshtm.ac.uk/id/eprint/8694

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