Vaccines against malaria - an update


Matuschewski, K; Mueller, AK; (2007) Vaccines against malaria - an update. The FEBS journal, 274 (18). pp. 4680-4687. ISSN 1742-464X DOI: 10.1111/j.1742-4658.2007.05998.x

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Abstract

Malaria vaccine discovery and development follow two principal strategies. Most subunit vaccines are designed to mimic naturally acquired immunity that develops over years upon continuous exposure to Plasmodium transmission. Experimental model vaccines, such as attenuated live parasites and transmission-blocking antigens, induce immune responses superior to naturally acquired immunity. The promises and hurdles of the different tracks towards an effective and affordable vaccine against malaria are discussed.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Vaccine Centre
PubMed ID: 17824954
Web of Science ID: 249164800003
URI: http://researchonline.lshtm.ac.uk/id/eprint/8589

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