Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C


Neeson, BN; Clark, GC; Atkins, HS; Lingard, B; Titball, RW; (2007) Analysis of protection afforded by a Clostridium perfringens alpha-toxoid against heterologous clostridial phospholipases C. Microbial pathogenesis, 43 (4). pp. 161-165. ISSN 0882-4010 DOI: 10.1016/j.micpath.2007.05.004

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Abstract

The major virulence determinant in clostridial myonecrosis caused by Clostridium perfringens is a phospholipase C (PLC), the a-toxin. Previously, mice have been protected against challenge with heterologous a-toxin or Clostridium perfringens spores by immunisation with the C-domain (known as Cpa(247-370) or alpha-toxoid) of the a-toxin. In this study, we have determined the ability of the a-toxoid to protect against the lethal effects of a divergent C. perfringens a-toxin and against the PLCs of C absonum or C. bifermentans, species which have been isolated from cases of clostridial myonecrosis. Protection against the C. perfringens g-toxin variant, the C absonum a-toxin or the C. bifermentans PLC was elicited by immunisation with the alpha-toxoid in vivo. Crown Copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Animals, Bacterial Toxins, immunology, Bacterial Vaccines, immunology, pharmacology, Calcium-Binding Proteins, immunology, Cattle, Clostridium Infections, enzymology, immunology, microbiology, prevention & control, Clostridium bifermentans, enzymology, Clostridium perfringens, immunology, Cross Reactions, Female, Mice, Mice, Inbred BALB C, Recombinant Proteins, biosynthesis, genetics, isolation & purification, pharmacology, Type C Phospholipases, antagonists & inhibitors, immunology, metabolism
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 17604945
Web of Science ID: 249271300003
URI: http://researchonline.lshtm.ac.uk/id/eprint/8583

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