Effect of Iodine Supplementation During Pregnancy on Infant Neurodevelopment at 1 Year of Age


Murcia, M; Rebagliato, M; Iniguez, C; Lopez-Espinosa, MJ; Estarlich, M; Plaza, B; Barona-Vilar, C; Espada, M; Vioque, J; Ballester, F; (2011) Effect of Iodine Supplementation During Pregnancy on Infant Neurodevelopment at 1 Year of Age. American journal of epidemiology, 173 (7). pp. 804-812. ISSN 0002-9262 DOI: https://doi.org/10.1093/aje/kwq424

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Abstract

Iodine is the main constituent of thyroid hormones, which in turn are required for fetal brain development. However, the relation between iodine intake during pregnancy, thyroid function, and child neurodevelopment needs further evaluation. The authors assessed the association of maternal iodine intake from diet and supplements during pregnancy and of maternal and neonatal thyroid function with infant neurodevelopment. The Mental Development Index and Psychomotor Development Index (PDI) for 691 children were obtained between 2005 and 2007 using the Bayley Scales of Infant Development at age 1 year in a prebirth cohort in Valencia, Spain. In multivariate analyses, a maternal thyrotropin level > 4 mu U/mL was associated with an increased risk of a PDI < 85 (odds ratio = 3.5, P = 0.02). Maternal intake of >= 150 mu g/day, compared with < 100 mu g/day, of iodine from supplements was associated with a 5.2-point decrease in PDI (95% confidence interval: -8.1, -2.2) and a 1.8-fold increase in the odds of a PDI < 85 (95% confidence interval: 1.0, 3.3). When analyses were stratified by sex, this association was intensified for girls but was not observed for boys. Further evidence on the safety and effectiveness of iodine supplementation during pregnancy is needed before it is systematically recommended in iodine-sufficient or mildly deficient areas.

Item Type: Article
Keywords: child development, dietary supplements, fetal development, iodine, prenatal nutritional physiological phenomena, thyroid hormones, MATERNAL THYROID-FUNCTION, FETAL-BRAIN DEVELOPMENT, CHILD-DEVELOPMENT, NEUROPSYCHOLOGICAL DEVELOPMENT, WOMEN, DEFICIENCY, HYPOTHYROXINEMIA, HYPOTHYROIDISM, HORMONE, RECOMMENDATIONS
Faculty and Department: Faculty of Public Health and Policy > Dept of Social and Environmental Health Research
PubMed ID: 21385833
Web of Science ID: 289301200012
URI: http://researchonline.lshtm.ac.uk/id/eprint/846

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