Diverse genotypes of Kaposi's sarcoma associated herpesvirus (KSHV) identified in infant blood infections in African childhood-KS and HIV/AIDS endemic region

Kasolo, FC; Spinks, J; Bima, H; Bates, M; Gompels, UA; (2007) Diverse genotypes of Kaposi's sarcoma associated herpesvirus (KSHV) identified in infant blood infections in African childhood-KS and HIV/AIDS endemic region. Journal of medical virology, 79 (10). pp. 1555-1561. ISSN 0146-6615 DOI: https://doi.org/10.1002/jmv.20952

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Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) has been associated with several neoplasias, including childhood endemic Kaposi's sarcoma (KS). It is possible that strain genotypes could contribute to the differences in regional presentation (mainly sub-Saharan Africa), childhood infection, lack of male sex bias, distinct disseminated forms and rapid fatality observed for childhood endemic KS. Early studies, at the advent of the HIV/AIDS epidemic, identified only the K1-A5 genotype in childhood KS biopsies as well as blood of a few HIV positive and negative febrile infants in Zambia, a highly endemic region. This current enlarged study analyses blood infections of 200 hospitalized infants (6-34 months age) with symptoms of fever as well as upper respiratory tract infection, diarrhoea, rash or rhinitis. KSHV and HIV viraemia and were prevalent in this group, 22% and 39%, respectively. Multiple markers at both variable ends of the genome (K1, K12, and K14.1/K15) were examined, showing diverse previously adult-linked genotypes (K1 A2, A5, 8, C3, D, with K12 131 and B2 plus K14.1/K15 P or M) detected in both HIV positive and negative infants, demonstrating little restriction on KSHV genotypes for infant/childhood transmission in a childhood endemic KS endemic region. This supports the interpretation that the acquisition of childhood KSHV infections and subsequent development of KS are due to additional co-factors.

Item Type: Article
Keywords: Amino Acid Sequence, Child, Preschool, Diarrhea, pathology, Endemic Diseases, prevention & control, Exanthema, pathology, Fever of Unknown Origin, pathology, virology, Genes, Viral, HIV Infections, Herpesvirus 8, Human, genetics, Humans, Infant, Molecular Sequence Data, Rhinitis, pathology, Sarcoma, Kaposi, epidemiology, Sequence Alignment, Viral Proteins, genetics, Viremia, Zambia, epidemiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 17705172
Web of Science ID: 248971600016
URI: http://researchonline.lshtm.ac.uk/id/eprint/8448


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