Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.
Musonda, Chitalu C;
Little, Susan;
Yardley, Vanessa;
Chibale, Kelly;
(2007)
Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.
Bioorganic & medicinal chemistry letters, 17 (17).
pp. 4733-4736.
ISSN 0960-894X
DOI: https://doi.org/10.1016/j.bmcl.2007.06.070
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The synthesis and antimalarial activity of a novel series of first generation 4-aminoquinoline-containing 2,4,5-trisubstituted aminoxazoles against two strains of the Plasmodium falciparum parasite in vitro is described. A number of compounds significantly more potent than the standard drug chloroquine were identified.