Aerosol and subcutaneous measles vaccine: Measles antibody responses 6 years after re-vaccination


Dilraj, A; Sukhoo, R; Cutts, FT; Bennett, JV; (2007) Aerosol and subcutaneous measles vaccine: Measles antibody responses 6 years after re-vaccination. Vaccine, 25 (21). pp. 4170-4174. ISSN 0264-410X DOI: 10.1016/j.vaccine.2007.03.003

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Abstract

There are no large-scale data on the long-term persistence of measles antibody after vaccination by the aerosol route. We therefore followed-up South African schoolchildren 6 years after their re-vaccination with Edmonston-Zagreb (EZ) and Schwarz (SW) measles vaccine given by aerosol and subcutaneous routes. Measles antibody levels and the proportion of children who were seropositive at year 6 remained significantly higher in the Edmonston-Zagreb aerosol group compared to the groups that received Schwarz or Edmonston-Zagreb vaccine subcutaneously. Measles re-vaccination by aerosol evokes a stronger and much Ion er lasting antibody response than injected vaccine and should thus provide more durable protection against measles. (c) 2007 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Adolescent, Aerosols, Antibodies, Viral, blood, Child, Child, Preschool, Female, Humans, Injections, Subcutaneous, Male, Measles, immunology, prevention & control, Measles Vaccine, administration & dosage, immunology, Measles virus, immunology, South Africa, Time Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 17408818
Web of Science ID: 247640900007
URI: http://researchonline.lshtm.ac.uk/id/eprint/8431

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