How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions?


Sutherland, CJ; Drakeley, CJ; Schellenberg, D; (2007) How is childhood development of immunity to Plasmodium falciparum enhanced by certain antimalarial interventions? Malar J, 6. p. 161. ISSN 1475-2875 DOI: 10.1186/1475-2875-6-161

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Abstract

The development of acquired protective immunity to Plasmodium falciparum infection in young African children is considered in the context of three current strategies for malaria prevention: insecticide-impregnated bed nets or curtains, anti-sporozoite vaccines and intermittent preventive therapy. Evidence is presented that each of these measures may permit attenuated P. falciparum blood-stage infections, which do not cause clinical malaria but can act as an effective blood-stage "vaccine". It is proposed that the extended serum half-life, and rarely considered liver-stage prophylaxis provided by the anti-folate combination sulphadoxine-pyrimethamine frequently lead to such attenuated infections in high transmission areas, and thus contribute to the sustained protection from malaria observed among children receiving the combination as intermittent preventative therapy or for parasite clearance in vaccine trials.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 18053225
Web of Science ID: 252279300002
URI: http://researchonline.lshtm.ac.uk/id/eprint/8328

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