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Bousema, JT; Drakeley, CJ; Mens, PF; Arens, T; Houben, R; Omar, SA; Gouagna, LC; Schallig, H; Sauerwein, RW; (2008) Increased Plasmodium falciparum Gametocyte Production in Mixed Infections with P. malariae. The American journal of tropical medicine and hygiene, 78 (3). pp. 442-8. ISSN 0002-9637

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Abstract

: Plasmodium falciparum and P. malariae occur endemically in many parts of Africa. Observations from malariotherapy patients suggest that co-infection with P. malariae may increase P. falciparum gametocyte production. We determined P. falciparum gametocyte prevalence and density by quantitative nucleic acid sequence-based amplification (QT-NASBA) after antimalarial treatment of Kenyan children with either P. falciparum mono-infection or P. falciparum and P. malariae mixed infection. In addition, we analyzed the relationship between mixed species infections and microscopic P. falciparum gametocyte prevalence in three datasets from previously published studies. In Kenyan children, QT-NASBA gametocyte density was increased in mixed species infections (P = 0.03). We also observed higher microscopic prevalences of P. falciparum gametocytes in mixed species infections in studies from Tanzania and Kenya (odds ratio = 2.15, 95% confidence interval = 0.99-4.65 and 2.39, 1.58-3.63) but not in a study from Nigeria. These data suggest that co-infection with P. malariae is correlated with increased P. falciparum gametocytemia.<br/>

Item Type:	Article
Faculty and Department:	Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre:	Malaria Centre
PubMed ID:	18337341
Web of Science ID:	253928100018
URI:	http://researchonline.lshtm.ac.uk/id/eprint/8115

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