Synthesis and In Vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives


Khrizman, A; Slack, RD; Remsing, RC; Little, S; Yardley, V; Moyna, G; (2007) Synthesis and In Vitro protozoocidal evaluation of novel diazabicyclic tropolone derivatives. Archiv der Pharmazie, 340 (11). pp. 569-576. ISSN 0365-6233 DOI: https://doi.org/10.1002/ardp.200700143

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Abstract

The synthesis and in vitro antiparasitic activity of twenty-seven novel diazabicycles based on tropolone ethers is presented. The compounds can be readily prepared by means of a high-yielding hetero Diels -Alder reaction using simple and readily available starting materials. Several of the new diazabicycles have in vitro activities against Trypanosoma cruzi, Leishmania donovani, Trypanosoma brucei rhodesiense, and chloroquine-resistant Plasmodium falciparum that are comparable or superior to those of currently employed protozoocidal agents.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
Web of Science ID: 251202400001
URI: http://researchonline.lshtm.ac.uk/id/eprint/7892

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