Malaria: progress, perils, and prospects for eradication.


Greenwood, BM; Fidock, DA; Kyle, DE; Kappe, SH; Alonso, PL; Collins, FH; Duffy, PE; (2008) Malaria: progress, perils, and prospects for eradication. The Journal of clinical investigation, 118 (4). pp. 1266-1276. ISSN 0021-9738 DOI: 10.1172/JCI33996

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Abstract

There are still approximately 500 million cases of malaria and 1 million deaths from malaria each year. Yet recently, malaria incidence has been dramatically reduced in some parts of Africa by increasing deployment of anti-mosquito measures and new artemisinin-containing treatments, prompting renewed calls for global eradication. However, treatment and mosquito control currently depend on too few compounds and thus are vulnerable to the emergence of compound-resistant parasites and mosquitoes. As discussed in this Review, new drugs, vaccines, and insecticides, as well as improved surveillance methods, are research priorities. Insights into parasite biology, human immunity, and vector behavior will guide efforts to translate parasite and mosquito genome sequences into novel interventions.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Disease Control
Research Centre: Malaria Centre
PubMed ID: 18382739
Web of Science ID: 254588600019
URI: http://researchonline.lshtm.ac.uk/id/eprint/7810

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