Kinetoplastids: related protozoan pathogens, different diseases.


Stuart, K; Brun, R; Croft, S; Fairlamb, A; Gürtler, RE; McKerrow, J; Reed, S; Tarleton, R; (2008) Kinetoplastids: related protozoan pathogens, different diseases. The Journal of clinical investigation, 118 (4). pp. 1301-1310. ISSN 0021-9738 DOI: https://doi.org/10.1172/JCI33945

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Abstract

Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the genomes of some of these species has highlighted their genetic relatedness and underlined differences in the diseases that they cause. As we discuss in this Review, steady progress using a combination of molecular, genetic, immunologic, and clinical approaches has substantially increased understanding of these pathogens and important aspects of the diseases that they cause. Consequently, the paths for developing additional measures to control these "neglected diseases" are becoming increasingly clear, and we believe that the opportunities for developing the drugs, diagnostics, vaccines, and other tools necessary to expand the armamentarium to combat these diseases have never been better.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Leishmaniasis Group
PubMed ID: 18382742
Web of Science ID: 254588600022
URI: http://researchonline.lshtm.ac.uk/id/eprint/7809

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