Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities.


Churchyard, GJ; Scano, F; Grant, AD; Chaisson, RE; (2007) Tuberculosis preventive therapy in the era of HIV infection: overview and research priorities. The Journal of infectious diseases, 196 Suppl 1. S52-62. ISSN 0022-1899 DOI: https://doi.org/10.1086/518662

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Abstract

The recognition of tuberculosis (TB) as a major cause of morbidity and mortality among human immunodeficiency virus (HIV)-infected persons has led to renewed interest in TB preventive therapy and its incorporation into the essential package of health care for these individuals. Despite convincing data regarding its efficacy, TB preventive therapy has not been widely implemented. Further work is needed to determine how to overcome the barriers to the implementation of such therapy, including how best to exclude the presence of active TB before providing preventive therapy. Such issues as the optimal duration of preventive therapy for and the role of TB preventive therapy in the treatment of individuals receiving antiretroviral therapy remain to be defined. Ongoing research will help to determine how best to use this intervention in the care of HIV-infected persons and in the control of TB on a wider basis.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: TB Centre
PubMed ID: 17624827
Web of Science ID: 248045700008
URI: http://researchonline.lshtm.ac.uk/id/eprint/7797

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