Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia


Mendy, ME; McConkey, SJ; van der Sande, MAB; Crozier, S; Kaye, S; Jeffries, D; Hall, AJ; Whittle, HC; (2008) Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia. Virology Journal, 5. ISSN 1743-422X DOI: 10.1186/1743-422X-5-49

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Abstract

Background: Little is known about changes in hepatitis B viral load (HBV DNA) in relation to age in Africa. The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA levels and hepatitis B surface (HBsAg) antigen/hepatitis e antigen (HBeAg) status by age. Methods: The study was conducted on 190 HBV chronic carriers, aged 1-19 years who were followed for 19 years. 160, 99 and 123 were traced at 5, 9 and 19 years later. All available samples were tested for HBsAg and HBeAg, whilst 170, 61, 63 and 81 were tested for HBV DNA at the baseline, and at 5, 9 and 19 years following recruitment. Results: In general HBeAg which correlated with high levels of HBV DNA was lost at a much faster rate than HBsAg. 86% of the carriers who were recruited at the age of 1-4 yrs lost HBeAg by the age of 19 years compared to 30% who lost HBsAg. HBeAg negative carriers had serum HBV DNA levels of < 10(5) copies per mL, HBV DNA positivity declined from 100% in 1-4 yrs old carriers at recruitment to 62.5%, 60% and 88% at 5, 9 and 19 years respectively following recruitment. Conclusion: After 19 years of follow up, the majority of HBV surface antigen carriers had lost HBeAg positivity and had low levels of viral replication. However small proportions (10-20%) retained HBeAg and continue to have high levels of viral replication.

Item Type: Article
Keywords: HEPATITIS-B-VIRUS, HEPATOCELLULAR-CARCINOMA, E-ANTIGEN, SURFACE-ANTIGEN, NATURAL-HISTORY, PLASMA DNA, INFECTION, RISK, VACCINATION, CARRIAGE, Adolescent, Adult, Age Factors, Carrier State, virology, Child, Child, Preschool, DNA, Viral, blood, Female, Gambia, Hepatitis B Surface Antigens, blood, Hepatitis B e Antigens, blood, Hepatitis B, Chronic, virology, Humans, Infant, Longitudinal Studies, Male, Viral Load
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID: 18416832
Web of Science ID: 255476700001
URI: http://researchonline.lshtm.ac.uk/id/eprint/7565

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