Risk factors for sporadic Creutzfeldt-Jakob disease

Ward, HJT; Everington, D; Cousens, SN; Smith-Bathgate, B; Gillies, M; Murray, K; Knight, RSG; Smith, PG; Will, RG; (2008) Risk factors for sporadic Creutzfeldt-Jakob disease. Annals of neurology, 63 (3). pp. 347-354. ISSN 0364-5134 DOI: https://doi.org/10.1002/ana.21294

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Objective: Although surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, these iatrogenic cases account for only a small proportion of all CJD cases. The majority are sporadic CJD (sCJD) cases of unknown cause. This study investigated whether some cases classified as sCJD might have an unrecognized iatrogenic basis through surgical or other medical procedures. Methods: This study compared medical risk factors from 431 sCJD cases referred 1998 to 2006 with 454 population control subjects. Possible geographic and temporal links between neurological and gynecological operations in 857 sCJD cases referred from 1990 to 2006 were investigated. Results: A reported history of ever having undergone Surgery was associated with increased risk for sCJD (odds ratio, 2.0; 95% confidence interval, 1.3-2.1; p = 0.003). Increased risk was not associated with surgical categories chosen a priori but was confined to the residual category "other surgery," in which the increase in risk appeared most marked for three subcategories: skin stitches, nose/throat operations, and removal of growths/cysts/moles. No convincing evidence was found of links (same hospital, within 2 years) between cases undergoing neurosurgery or gynecological surgery. Interpretation: It is unlikely that a high proportion of UK sCJD cases are the result of transmission during surgery, but we cannot exclude the possibility that such transmission occurs occasionally. A study based on accurate surgical histories obtained from medical records is required to determine whether the increased risk associated with reported surgical history reflects a causal association or recall bias.

Item Type: Article
Keywords: PERSON TRANSMISSION, PRION PROTEIN, VARIANT, SURGERY, SURVEILLANCE, Adult, Aged, Aged, 80 and over, Case-Control Studies, Creutzfeldt-Jakob Syndrome, epidemiology, etiology, transmission, Female, Gynecologic Surgical Procedures, adverse effects, Humans, Male, Middle Aged, Neurosurgical Procedures, adverse effects, Risk Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
Tropical Epidemiology Group
PubMed ID: 18074392
Web of Science ID: 254642500012
URI: http://researchonline.lshtm.ac.uk/id/eprint/7548


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