Optimizing the design of clinical trials where the outcome is a rate. Can estimating a baseline rate in a run-in period increase efficiency?

Frost, C; Kenward, MG; Fox, NC; (2008) Optimizing the design of clinical trials where the outcome is a rate. Can estimating a baseline rate in a run-in period increase efficiency? Statistics in medicine, 27 (19). pp. 3717-31. ISSN 0277-6715 DOI: https://doi.org/10.1002/sim.3280

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