Herpes simplex type 2 (HSV-2) trends in relation to the HIV epidemic in northern Malawi.


Glynn, JR; Crampin, AC; Ngwira, BM; Ndhlovu, R; Mwanyongo, O; Fine, PE; (2008) Herpes simplex type 2 (HSV-2) trends in relation to the HIV epidemic in northern Malawi. Sexually transmitted infections, 84 (5). pp. 356-60. ISSN 1368-4973 DOI: 10.1136/sti.2008.030056

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Abstract

OBJECTIVES: It is unclear whether the high prevalence of herpes simplex virus type 2 (HSV-2) found in much of Africa predates the HIV epidemic or is, to some extent, a consequence of it. HSV-2 prevalence trends in a rural African community were assessed over a period in which HIV prevalence rose sharply, and antenatal clinic (ANC) surveillance was explored as a method of estimating community HSV-2 prevalence. METHODS: HSV-2 seroprevalence was determined among community controls seen for case-control studies of mycobacterial disease in Karonga district, Malawi, in 1988-90, 1998-2001 and 2002-5, and in women attending ANC as part of surveillance for HIV in 1999-2000. Over this period HIV prevalence rose from 4% to 12%. RESULTS: HSV-2 prevalence in all periods increased sharply with age and was higher in women than in men. After excluding migrants, there was no evidence of change in HSV-2 prevalence in the different periods. Women in the ANC group had lower HSV-2 prevalence than those in the community, but the ANC prevalence was a good approximation to the combined male and female prevalence for the same age group. CONCLUSIONS: This study suggests that HSV-2 was already widespread before the HIV epidemic and has not been greatly influenced by it. It also demonstrates that ANC surveillance may be useful for estimating community HSV-2 prevalence.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: MEIRU
PubMed ID: 18524842
Web of Science ID: 259401800008
URI: http://researchonline.lshtm.ac.uk/id/eprint/7530

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