Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.


Sirugo, G; Hennig, BJ; Adeyemo, AA; Matimba, A; Newport, MJ; Ibrahim, ME; Ryckman, KK; Tacconelli, A; Mariani-Costantini, R; Novelli, G; Soodyall, H; Rotimi, CN; Ramesar, RS; Tishkoff, SA; Williams, SM; (2008) Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics. Human genetics, 123 (6). pp. 557-98. ISSN 0340-6717 DOI: https://doi.org/10.1007/s00439-008-0511-y

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Abstract

Africa is the ultimate source of modern humans and as such harbors more genetic variation than any other continent. For this reason, studies of the patterns of genetic variation in African populations are crucial to understanding how genes affect phenotypic variation, including disease predisposition. In addition, the patterns of extant genetic variation in Africa are important for understanding how genetic variation affects infectious diseases that are a major problem in Africa, such as malaria, tuberculosis, schistosomiasis, and HIV/AIDS. Therefore, elucidating the role that genetic susceptibility to infectious diseases plays is critical to improving the health of people in Africa. It is also of note that recent and ongoing social and cultural changes in sub-Saharan Africa have increased the prevalence of non-communicable diseases that will also require genetic analyses to improve disease prevention and treatment. In this review we give special attention to many of the past and ongoing studies, emphasizing those in Sub-Saharan Africans that address the role of genetic variation in human disease.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18512079
Web of Science ID: 256659100001
URI: http://researchonline.lshtm.ac.uk/id/eprint/7520

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