Predictors of patterns of change in health-related quality of life in older women over 7 years: evidence from a prospective cohort study.


Dale, CE; Bowling, A; Adamson, J; Kuper, H; Amuzu, A; Ebrahim, S; Casas, JP; Nüesch, E; (2013) Predictors of patterns of change in health-related quality of life in older women over 7 years: evidence from a prospective cohort study. Age and ageing, 42 (3). pp. 312-8. ISSN 0002-0729 DOI: https://doi.org/10.1093/ageing/aft029

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Abstract

BACKGROUND: the evaluation of the determinants of change over time in health-related quality of life (HR-QoL) in older people is limited. This study aims to identify patterns of change in HR-QoL over 7 years and their determinants using data from the British Women's Heart and Health Study, a representative sample of older women (n = 4286).<br/> METHODS: longitudinal latent class analysis was used to identify subpopulations of women with similar HR-QoL trajectories from 1999-2000 to 2007. HR-QoL was measured using the EQ-5D. Multivariate multinomial logistic regression was used to model the association of identified trajectories with baseline predictors after multiple imputation of missing data.<br/> RESULTS: four distinct EQ-5D trajectories were suggested: high (19% of women), high decline (22%), intermediate (42%) and low decline (16%). Prevalent arthritis (OR = 13.4; 95% CI: 8.8, 20.5), diabetes (OR = 4.6; 95% CI: 1.5, 14.2) and obesity (OR = 3.9; 95% CI: 2.5, 6.0) were the strongest predicting health conditions of adverse changes in HR-QoL and physical activity the strongest predicting lifestyle factor (OR = 2.8; 95% CI: 2.0, 3.9).<br/> CONCLUSIONS: findings suggest that older women without obesity or pre-existing health conditions who undertake more physical activity are more likely to experience high HR-QoL, reinforcing the importance of these factors for healthy ageing.<br/>

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- ) > Dept of Nutrition and Public Health Interventions Research (2003-2012)
Faculty of Epidemiology and Population Health > Dept of Population Health (2012- )
Research Centre: The International Centre for Evidence in Disability
Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 23537589
Web of Science ID: 318552800009
URI: http://researchonline.lshtm.ac.uk/id/eprint/748752

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