Leprosy occurring as immune reconstitution syndrome.

Deps, PD; Lockwood, DN; (2008) Leprosy occurring as immune reconstitution syndrome. Transactions of the Royal Society of Tropical Medicine and Hygiene, 102 (10). pp. 966-8. ISSN 0035-9203 DOI: https://doi.org/10.1016/j.trstmh.2008.06.003

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Immune reconstitution inflammatory syndrome (IRIS) may occur in HIV-infected patients after starting highly active antiretroviral therapy (HAART). Since 2003, 19 cases were published as IRIS. Leprosy has been reported as an example of an IRIS, and it is important that this syndrome should be recognized in leprosy-endemic areas. The case definition of leprosy as IRIS is based on clinical presentation of leprosy, evidence of immune restoration and timing of onset. Case definition should include the following: (1) leprosy and/or leprosy type 1 reaction presenting within six months of starting HAART; (2) advanced HIV infection; (3) low CD4+ count before start HAART; (4) CD4+ count increasing after HAART has been started. Although pathogenic mechanisms are still unclear, it is likely that leprosy-associated IRIS will be increasingly reported in those countries endemic for both diseases and as access to HAART becomes more widely available.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 18639911
Web of Science ID: 260083000003
URI: http://researchonline.lshtm.ac.uk/id/eprint/7392


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