Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis.


Heikkila, K; Harris, R; Lowe, G; Rumley, A; Yarnell, J; Gallacher, J; Ben-Shlomo, Y; Ebrahim, S; Lawlor, DA; (2008) Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer causes & control, 20 (1). pp. 15-26. ISSN 0957-5243 DOI: https://doi.org/10.1007/s10552-008-9212-z

Full text not available from this repository. (Request a copy)

Abstract

OBJECTIVE: We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. METHODS: We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45-59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses. RESULTS: CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk. CONCLUSIONS: Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Faculty of Public Health and Policy > Dept of Health Services Research and Policy
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18704713
Web of Science ID: 262504100002
URI: http://researchonline.lshtm.ac.uk/id/eprint/7361

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
289Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item