Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients


Clayton, LM; Devile, M; Punte, T; Kallis, C; de Haan, GJ; Sander, JW; Acheson, J; Sisodiya, SM; (2011) Retinal Nerve Fiber Layer Thickness in Vigabatrin-Exposed Patients. Annals of neurology, 69 (5). pp. 845-854. ISSN 0364-5134 DOI: https://doi.org/10.1002/ana.22266

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Abstract

Objective: Vigabatrin-associated visual field loss (VAVFL) occurs in 25 to 50% of exposed patients and is routinely monitored using perimetry, which has inherent limitations. Using optical coherence tomography (OCT), retinal nerve fiber layer (RNFL) thinning has been described in a small number of vigabatrin-exposed patients. We explored the relationship between RNFL thickness and visual field size, to determine whether OCT is a suitable tool to use in patients exposed to vigabatrin. Methods: Two hundred one vigabatrin-exposed subjects with epilepsy, divided into 2 groups, and 90 healthy controls participated. Visual fields were obtained using Goldmann kinetic perimetry and quantified using mean radial degrees (MRD). RNFL imaging was performed using either spectral-domain (Group 1) or time-domain (Group 2) OCT. Results: Thirty-nine of 201 (19.4%) patients were unable to perform perimetry. Thirteen (6.5%) patients were unable to perform OCT. A total of 51.6% of patients showed VAVFL. Average RNFL thickness was significantly thinner in patients (77.9 mu m) compared to healthy controls (93.6 mu m) (p < 0.001). There was a strong correlation between MRD and average RNFL thickness for Group 1 (r = 0.768, p < 0.001) and Group 2 (r = 0.814, p < 0.001). OCT RNFL imaging showed high repeatability. Interpretation: OCT provides a useful tool to assess people exposed to vigabatrin, and can provide an accurate estimate of the extent of visual field loss in the absence of a reliable direct measure of the visual field. The strong linear relationship found between RNFL thickness and visual field size provides some evidence that irreversible VAVFL may be related to loss of retinal ganglion cell axons. ANN NEUROL 2011; 69: 845-854

Item Type: Article
Keywords: VISUAL-FIELD LOSS, OPTICAL COHERENCE TOMOGRAPHY, GABA-TRANSAMINASE, INHIBITOR, SPECTRAL-DOMAIN, ANTIEPILEPTIC DRUGS, GLAUCOMATOUS DAMAGE, LINEAR-MODEL, STRATUS OCT, TIME-DOMAIN, EPILEPSY
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 21246602
Web of Science ID: 290156300011
URI: http://researchonline.lshtm.ac.uk/id/eprint/724

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