Herpes simplex virus and HIV-1: deciphering viral synergy.

Van de Perre, P; Segondy, M; Foulongne, V; Ouedraogo, A; Konate, I; Huraux, JM; Mayaud, P; Nagot, N; (2008) Herpes simplex virus and HIV-1: deciphering viral synergy. The Lancet infectious diseases, 8 (8). pp. 490-7. ISSN 1473-3099 DOI: https://doi.org/10.1016/S1473-3099(08)70181-6

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Recent proof-of-concept randomised controlled trials have shown a causal relation between herpes simplex virus (HSV) type 2 infection and HIV-1 replication in co-infected individuals. We explore the mechanisms that may operate to enhance reciprocal viral replication. Direct interactions could involve HIV-1-related immune deficiency, disruption of mucosal barrier by HSV infection/reactivation, HSV-induced mucosal cell recruitment, transactivation of HIV-1 replication by HSV proteins, and immune modulation by HSV decoys. Indirect interactions might coexist through disturbances of the vaginal flora during HSV shedding and systemic immune activation. In co-infected individuals, suppressive HSV treatment reduces HIV-1 genital and systemic excretion. This finding is a likely result of efficacious prevention of HSV2 reactivations, and perhaps of other herpesviruses. Strategies to control HSV2 and other herpesviruses deserve urgent attention and should become part of the HIV-1 prevention and care package.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
Research Centre: Centre for Maternal, Reproductive and Child Health (MARCH)
PubMed ID: 18652995
Web of Science ID: 258024800018
URI: http://researchonline.lshtm.ac.uk/id/eprint/7013


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