C-reactive protein and coronary heart disease: a critical review.

Casas, JP; Shah, T; Hingorani, AD; Danesh, J; Pepys, MB; (2008) C-reactive protein and coronary heart disease: a critical review. Journal of internal medicine, 264 (4). pp. 295-314. ISSN 0954-6820 DOI: https://doi.org/10.1111/j.1365-2796.2008.02015.x

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Modestly elevated baseline concentrations of C-reactive protein (CRP), the classical acute phase protein, are associated with the long-term risk of coronary heart disease in general populations, whilst the major acute phase response of CRP following myocardial infarction is associated with death and cardiac complications. The pathogenic and clinical significance of these associations is controversial. Here we critically review the evidence and describe large-scale epidemiological studies, novel experiments and possible specific therapies which will rigorously inform the debate. We distinguish between the potential pathogenicity of high acute phase circulating CRP concentrations in individuals with substantial tissue damage and modest but persistent increases in baseline values in generally healthy subjects.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 18823504
Web of Science ID: 259152400001
URI: http://researchonline.lshtm.ac.uk/id/eprint/6980


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