Modeling future changes to the meningococcal serogroup C conjugate (MCC) vaccine program in England and Wales


Trotter, CL; Edmunds, WJ; Ramsay, ME; Miller, E; (2006) Modeling future changes to the meningococcal serogroup C conjugate (MCC) vaccine program in England and Wales. Human vaccines, 2 (2). pp. 68-73. ISSN 1554-8600 DOI: 10.4161/hv.2.2.2611

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Abstract

The UK meningococcal serogroup C conjugate (MCC) vaccine program has successfully controlled serogroup C disease, due to high vaccine effectiveness and substantial herd immunity. However, children immunised at 2, 3 and 4 months of age receive only short-term direct protection and may be at risk of disease 15 months after vaccination. To investigate this we applied a mathematical model to predict the future epidemiology of serogroup C disease, with and without changes to the immunization schedule. Only a few cases of serogroup C disease were predicted to occur over the next few years because of persisting herd immunity, even without a change to the vaccine schedule. The inclusion of a booster dose is likely to improve the impact of the MCC program and reducing the number of doses in infancy will improve cost-effectiveness and create space in the schedule for the addition of other vaccines.

Item Type: Article
Keywords: Adolescent, Algorithms, Carrier State/epidemiology/immunology, Cost-Benefit Analysis, England/epidemiology, Female, Forecasting, Humans, Immunity, Herd, Immunization Schedule, Male, Meningococcal Infections/epidemiology/*immunology/*prevention & control, Meningococcal Vaccines/economics/*immunology, Models, Statistical, Neisseria lactamica/immunology, Vaccines, Conjugate/economics/immunology, Wales/epidemiology, Adolescent, Algorithms, Carrier State, epidemiology, immunology, Cost-Benefit Analysis, England, epidemiology, Female, Forecasting, Humans, Immunity, Herd, Immunization Schedule, Male, Meningococcal Infections, epidemiology, immunology, prevention & control, Meningococcal Vaccines, economics, immunology, Models, Statistical, Neisseria lactamica, immunology, Vaccines, Conjugate, economics, immunology, Wales, epidemiology
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 17012888
Web of Science ID: 243979200004
URI: http://researchonline.lshtm.ac.uk/id/eprint/6821

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