Outcome of retinoblastoma in east Africa

Bowman, RJC; Mafwiri, M; Luthert, P; Luande, J; Wood, A; (2008) Outcome of retinoblastoma in east Africa. Pediatric blood & cancer, 50 (1). pp. 160-162. ISSN 1545-5009 DOI: https://doi.org/10.1002/pbc.21080

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We estimated the proportion of patients reaching a pediatric ophthalmology unit (Comprehensive Community Based Rehabilitation for Tanzania Disability Hospital, CCBRT) or an oncology unit (ORCI) in east Africa and investigated presentation, histology, and treatment outcomes of patients with retinoblastoma. A 5-year retrospective study identified 91 patients, representing approximately 18% of the nationwide total. Mean lag time was 10 months (standard deviation (SD)=17) and mean follow-up was 8 months (SD=11, range 0-40, n=91). Thirty months disease-free survival probability was 0.23 (standard error=0.07). Outcomes for retinoblastoma in Africa remain poor. The data presented here suggest strategies for improving the outcomes, including encouraging earlier presentation and establishment of multi-disciplinary treatment centers.

Item Type: Article
Keywords: Child, Preschool, Disease-Free Survival, Female, Humans, Incidence, Male, Retinal Neoplasms, epidemiology, surgery, Retinoblastoma, epidemiology, surgery, Tanzania, epidemiology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Clinical Research
PubMed ID: 17120241
Web of Science ID: 251410400036
URI: http://researchonline.lshtm.ac.uk/id/eprint/679485


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