LSHTM Research Online

Brisson, M; Edmunds, WJ; (2003) Economic evaluation of vaccination programs: the impact of herd-immunity. Medical decision making , 23 (1). pp. 76-82. ISSN 0272-989X

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Abstract

The unique characteristic of vaccination is that it not only reduces the incidence of disease in those immunized but also indirectly protects nonvaccinated susceptibles against infection (produces herd-immunity). The bulk of economic evaluations of vaccination programs continue to use models that cannot take into account the indirect effects produced by herd-immunity. Here, the authors illustrate the importance of incorporating herd-immunity externalities when assessing the cost-effectiveness of vaccination progams. To do this, they compare 2 methods of estimating the benefits of routine mass vaccination: one that includes herd-immunity (dynamic approach) and one that does not (static approach). Finally, they use the results to clarify a number of misconceptions that are common in the literature concerning herd-immunity and dynamical effects produced by models.

Item Type:	Article
Keywords:	Adolescent, Adult, Age Factors, Aged, Chickenpox/epidemiology/prevention & control/transmission, Child, Child, Preschool, Computer Simulation, Cost-Benefit Analysis/*statistics & numerical data, England/epidemiology, Humans, *Immunity, Herd, Incidence, Infant, Infant, Newborn, Mass Immunization/*economics, Middle Aged, *Models, Statistical, Wales/epidemiology, Adolescent, Adult, Age Factors, Aged, Chickenpox, epidemiology, prevention & control, transmission, Child, Child, Preschool, Computer Simulation, Cost-Benefit Analysis, statistics & numerical data, England, epidemiology, Humans, Immunity, Herd, Incidence, Infant, Infant, Newborn, Mass Immunization, economics, Middle Aged, Models, Statistical, Wales, epidemiology
Faculty and Department:	Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
PubMed ID:	12583457
Web of Science ID:	180665300007
URI:	http://researchonline.lshtm.ac.uk/id/eprint/6791

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