Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpox

Brisson, M; Gay, NJ; Edmunds, WJ; Andrews, NJ; (2002) Exposure to varicella boosts immunity to herpes-zoster: implications for mass vaccination against chickenpox. Vaccine, 20 (19-20). pp. 2500-7. ISSN 0264-410X DOI: https://doi.org/10.1016/S0264-410X(02)00180-9

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We present data to confirm that exposure to varicella boosts immunity to herpes-zoster. We show that exposure to varicella is greater in adults living with children and that this exposure is highly protective against zoster (Incidence ratio=0.75, 95% CI, 0.63-0.89). The data is used to parameterise a mathematical model of varicella zoster virus (VZV) transmission that captures differences in exposure to varicella in adults living with and without children. Under the 'best-fit' model, exposure to varicella is estimated to boost cell-mediated immunity for an average of 20 years (95% CI, 7-41years). Mass varicella vaccination is expected to cause a major epidemic of herpes-zoster, affecting more than 50% of those aged 10-44 years at the introduction of vaccination.

Item Type: Article
Keywords: Adolescent, Adult, Aged, Chickenpox/*immunology, Chickenpox Vaccine/*administration & dosage, Herpes Zoster/*immunology, Humans, Immunization Programs, Middle Aged, Adolescent, Adult, Aged, Chickenpox, immunology, Chickenpox Vaccine, administration & dosage, Herpes Zoster, immunology, Humans, Immunization Programs, Middle Aged
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Research Centre: Vaccine Centre
PubMed ID: 12057605
Web of Science ID: 176456200010
URI: http://researchonline.lshtm.ac.uk/id/eprint/6784


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