Are serum alpha- and beta-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes?


Prasad, M; Takkinen, HM; Nevalainen, J; Ovaskainen, ML; Alfthan, G; Uusitalo, L; Kenward, MG; Veijola, R; Simell, O; Ilonen, J; Knip, M; Virtanen, SM; (2011) Are serum alpha- and beta-carotene concentrations associated with the development of advanced beta-cell autoimmunity in children with increased genetic susceptibility to type 1 diabetes? Diabetes & metabolism, 37 (2). pp. 162-167. ISSN 1262-3636 DOI: https://doi.org/10.1016/j.diabet.2010.10.002

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Abstract

Aim. - Reactive oxygen intermediates have been implicated in mediating the destruction of insulin-producing beta cells and antioxidant nutrients thought to protect against such a process. This study aimed to assess the associations between serum alpha- and beta-carotene concentrations, and the risk of advanced beta-cell autoimmunity, in children with HLA-conferred susceptibility to type 1 diabetes. Methods. - This case-control study, comprising 108 case children with advanced beta-cell autoimmunity and 216 matched control children, was nested within the nutrition study of the Type 1 Diabetes Prediction and Prevention (DIPP) birth cohort. Serum alpha- and beta-carotene samples were collected each year from the age of 1 to 6 years. For each case-control group, serum samples were analyzed up to the time of seroconversion in the case children. Associations were studied using a conditional logistic-regression model. Results. - Neither serum alpha- nor beta-carotene concentration was significantly associated with the risk of advanced beta-cell autoimmunity. There was marginal evidence (P = 0.049) of an inverse association between serum beta-carotene concentration and the risk of developing advanced beta-cell autoimmunity at a time closest to seroconversion after adjusting for parental education, maternal age, duration of gestation, diabetes in first-degree relatives, number of earlier deliveries and maternal smoking during pregnancy. Conclusion. - The present study data provided no clear evidence to support an association between serum alpha- or beta-carotene concentration and advanced beta-cell autoimmunity. (C) 2010 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Keywords: Aetiology, Beta-cell autoimmunity, Type 1 diabetes, Children, Carotenoids, HLA-CONFERRED SUSCEPTIBILITY, YOUNG-CHILDREN, PLASMA, RISK, POPULATION, MELLITUS, DIET
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 21144788
Web of Science ID: 290876400012
URI: http://researchonline.lshtm.ac.uk/id/eprint/658

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