Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study.


Andersen, AF; Carson, C; Watt, HC; Lawlor, DA; Avlund, K; Ebrahim, S; (2008) Life-course socio-economic position, area deprivation and Type 2 diabetes: findings from the British Women's Heart and Health Study. Diabetic medicine, 25 (12). pp. 1462-8. ISSN 0742-3071 DOI: https://doi.org/10.1111/j.1464-5491.2008.02594.x

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Abstract

OBJECTIVES: We examined whether area deprivation influenced risk of Type 2 diabetes, fasting blood glucose and insulin resistance over and above the effect of individual socio-economic position (SEP) measured across the life course. METHODS: A cross-sectional analysis of 4286 women aged 60 to 79 years from 457 British electoral wards in 23 towns. RESULTS: Area deprivation was positively associated with diagnosed [odds ratio (OR) 1.32, 95% confidence interval (CI) 1.13, 1.53, per quintile of area deprivation, n = 2895], but not undiagnosed Type 2 diabetes after adjustment for individual life-course SEP. This association was robust to adjustment for adult health behaviours and physiological risk factors. Insulin resistance [homeostasis model assessment (HOMA) score] increased by 1.90% (95% CI 0.01, 3.82, n = 2526) per quintile of area deprivation after adjustment for individual SEP, while fasting blood glucose increased by 0.69% (95% CI 0.16, 1.22, n = 2875) after adjustment for individual SEP. CONCLUSIONS: Area level deprivation independently influences diagnosed Type 2 diabetes, insulin resistance and fasting blood glucose. Examination of more specific characteristics of places is needed to understand the mechanisms by which these effects arise.

Item Type: Article
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Medical Statistics
Faculty of Epidemiology and Population Health > Dept of Non-Communicable Disease Epidemiology
Research Centre: Centre for Global Non-Communicable Diseases (NCDs)
PubMed ID: 19046246
Web of Science ID: 261249200013
URI: http://researchonline.lshtm.ac.uk/id/eprint/6558

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