Assembly of feline calicivirus-like particle and its immunogenicity.


Di Martino, B; Marsilio, F; Roy, P; (2007) Assembly of feline calicivirus-like particle and its immunogenicity. Veterinary microbiology, 120 (1-2). pp. 173-8. ISSN 0378-1135 DOI: https://doi.org/10.1016/j.vetmic.2006.10.021

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Abstract

Virus-like particles (VLPs) were produced in insect cells infected with a recombinant baculovirus containing the capsid gene of feline calicivirus strain F9 (FCV-F9). The FCV VLPs were morphologically and antigenically similar to the native virus and contained a single capsid protein with a molecular weight of approximately 60 kDa that reacted with FCV antiserum. Moreover, following immunization of rabbits, VLPs were able to elicit neutralizing antibodies against several FCV strains isolated from clinical samples. Our preliminary results showed that FCV-VLP could be considered a candidate vaccine against FCV infections.

Item Type: Article
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Pathogen Molecular Biology
PubMed ID: 17126499
URI: http://researchonline.lshtm.ac.uk/id/eprint/6402

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