IL-10: The master regulator of immunity to infection


Couper, KN; Blount, DG; Riley, EM; (2008) IL-10: The master regulator of immunity to infection. Journal of immunology (Baltimore, Md, 180 (9). pp. 5771-5777. ISSN 0022-1767 DOI: https://doi.org/10.4049/jimmunol.180.9.5771

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Abstract

IL-10 is an anti-inflammatory cytokine. During infection it inhibits the activity of Th1 cells, NK cells, and macrophages, all of which are required for optimal pathogen clearance but also contribute to tissue damage. In consequence, IL-10 can both impede pathogen clearance and ameliorate immunopathology. Many different types of cells can produce IL-10, with the majorsource of IL-10 varying in different tissues or during acute or chronic stages of the same infection. The priming of these various IL-10-producing populations during infections is not well understood and it is not clear whether the cellular source of IL-10 during infection dictates its cellular target and thus its outcome. In this article we review the biology of IL-10, its cellular sources, and its role in viral, bacterial, and protozoal infections.

Item Type: Article
Keywords: Animals, Bacterial Infections, immunology, pathology, Humans, Interleukin-10, immunology, Killer Cells, Natural, immunology, pathology, Macrophages, immunology, pathology, Organ Specificity, immunology, Protozoan Infections, immunology, pathology, Th1 Cells, immunology, pathology, Virus Diseases, immunology, pathology
Faculty and Department: Faculty of Infectious and Tropical Diseases > Dept of Immunology and Infection
Research Centre: Malaria Centre
PubMed ID: 18424693
Web of Science ID: 257507000005
URI: http://researchonline.lshtm.ac.uk/id/eprint/6351

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