The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis


Scott, SM; Knowles, CH; Wang, D; Yazaki, E; Picon, L; Wingate, DL; Lindberg, G; (2006) The nocturnal jejunal migrating motor complex: defining normal ranges by study of 51 healthy adult volunteers and meta-analysis. Neurogastroenterology and motility, 18 (10). pp. 927-935. ISSN 1350-1925 DOI: https://doi.org/10.1111/j.1365-2982.2006.00824.x

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Abstract

Interdigestive human small bowel motility is characterized by the migrating motor complex (MMC). The aims of this study were to: (i) establish the normal range of variables of the nocturnal jejunal MMC and (ii) incorporate these data in a subsequent meta-analysis. Eighty-one recordings were performed by prolonged (24 h) ambulatory manometry in 51 subjects in two centres. Quantitative analysis was undertaken of 419 Phase III and 332 Phase II episodes. Adjusted mean values of seven variables were calculated using a mixed-effects model. Meta-analysis of pooled published data to generate a reliable 95% reference range was also performed. Adjusted mean values and confidence intervals are presented for all seven variables. Intrasubject variances were large in comparison with intersubject. Meta-analysis of 19 studies (356 pooled patients) meeting inclusion criteria produced wide reference ranges. At least five such ranges are useful for the detection of abnormality in the individual. This is the largest study of normal volunteers presented to date, with ranges for many variables produced using appropriate statistical methodology. A model for definition of abnormality has been proposed. We recommend that these data may be used by investigators in this field as a complement to other existing indicators of small bowel dysmotility.

Item Type: Article
Keywords: human, meta-analysis, migrating motor complex, normal range, small, bowel manometry, IRRITABLE-BOWEL-SYNDROME, SMALL-INTESTINAL MANOMETRY, SLOW-TRANSIT, CONSTIPATION, INTERDIGESTIVE MOTILITY, AMBULATORY MANOMETRY, CHAGAS-DISEASE, HUMANS, ABNORMALITIES, PATTERNS, DYSMOTILITY, Adolescent, Adult, Circadian Rhythm, physiology, Gastrointestinal Motility, physiology, Humans, Jejunum, physiology, Manometry, Middle Aged, Monitoring, Ambulatory, Myoelectric Complex, Migrating, physiology, Reference Values, Time Factors
Faculty and Department: Faculty of Epidemiology and Population Health > Dept of Infectious Disease Epidemiology
Faculty of Epidemiology and Population Health > Dept of Medical Statistics
PubMed ID: 16961696
Web of Science ID: 240350200008
URI: http://researchonline.lshtm.ac.uk/id/eprint/6329

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