Xpert MTB/RIF for diagnosis of TB and drug-resistant TB: a cost and affordability analysis.


Pantoja, A; Fitzpatrick, C; Vassall, A; Weyer, K; Floyd, K; (2012) Xpert MTB/RIF for diagnosis of TB and drug-resistant TB: a cost and affordability analysis. The European respiratory journal. ISSN 0903-1936 DOI: https://doi.org/10.1183/09031936.00147912

Full text not available from this repository.

Abstract

: Xpert MTB/RIF is a rapid test to diagnose tuberculosis (TB) and rifampicin-resistant TB. Cost and affordability will influence its uptake.We assessed the cost, globally and in 36 high-burden countries (HBCs), of two strategies for diagnosing TB and multidrug-resistant TB (MDR-TB): Xpert with follow-on diagnostics, and conventional diagnostics. Costs were compared with funding available for TB care and control, and donor investments in HIV prevention and care.Using Xpert to diagnose MDR-TB would cost US$ 0.09 billion/year globally and be lower cost than conventional diagnostics globally and in all HBCs. Diagnosing TB in HIV-positive people using Xpert would also cost about US$ 0.10 billion/year and be lower cost than conventional diagnostics globally and in 33/36 HBCs. Testing everyone with TB signs and symptoms would cost almost US$ 0.47 billion/year globally, much more than conventional diagnostics. However, in European countries, Brazil and South Africa the cost would represent <10% of TB funding.Introducing Xpert to diagnose MDR-TB and to diagnose TB in HIV-positive people is warranted in many countries. Using it to test everyone with TB signs and symptoms is affordable in several middle-income countries, but financial viability in low-income countries requires large increases in TB funding and/or further price reductions.<br/>

Item Type: Article
Faculty and Department: Faculty of Public Health and Policy > Dept of Global Health and Development
Research Centre: Social and Mathematical Epidemiology (SaME)
SaME Modelling & Economics
PubMed ID: 23258774
Web of Science ID: 326160500021
URI: http://researchonline.lshtm.ac.uk/id/eprint/612465

Statistics


Download activity - last 12 months
Downloads since deposit
0Downloads
290Hits
Accesses by country - last 12 months
Accesses by referrer - last 12 months
Impact and interest
Additional statistics for this record are available via IRStats2

Actions (login required)

Edit Item Edit Item